IRF1 protein (Felis catus) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

IRF1

Interferon regulatory factor. (322 aa)

Predicted Functional Partners:

STAT1

0.975

HDAC1

0.942

HDAC2

0.942

MDM2

0.932

CHD4

0.909

STAT2

0.828

IRF8

0.803

STAT4

0.771

ISG15

0.746

STAT3

0.739

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHD4	HDAC1	ENSFCAP00000006385	ENSFCAP00000033351	Uncharacterized protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.979
CHD4	HDAC2	ENSFCAP00000006385	ENSFCAP00000035237	Uncharacterized protein.	Histone deacetylase 2.	0.983
CHD4	IRF1	ENSFCAP00000006385	ENSFCAP00000012353	Uncharacterized protein.	Interferon regulatory factor.	0.909
HDAC1	CHD4	ENSFCAP00000033351	ENSFCAP00000006385	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Uncharacterized protein.	0.979
HDAC1	HDAC2	ENSFCAP00000033351	ENSFCAP00000035237	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone deacetylase 2.	0.995
HDAC1	IRF1	ENSFCAP00000033351	ENSFCAP00000012353	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Interferon regulatory factor.	0.942
HDAC1	MDM2	ENSFCAP00000033351	ENSFCAP00000025067	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]	0.525
HDAC1	STAT1	ENSFCAP00000033351	ENSFCAP00000050611	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Signal transducer and activator of transcription.	0.669
HDAC1	STAT2	ENSFCAP00000033351	ENSFCAP00000011155	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Signal transducer and activator of transcription.	0.552
HDAC1	STAT3	ENSFCAP00000033351	ENSFCAP00000001991	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Signal transducer and activator of transcription.	0.574
HDAC1	STAT4	ENSFCAP00000033351	ENSFCAP00000015471	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Signal transducer and activator of transcription.	0.490
HDAC2	CHD4	ENSFCAP00000035237	ENSFCAP00000006385	Histone deacetylase 2.	Uncharacterized protein.	0.983
HDAC2	HDAC1	ENSFCAP00000035237	ENSFCAP00000033351	Histone deacetylase 2.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.995
HDAC2	IRF1	ENSFCAP00000035237	ENSFCAP00000012353	Histone deacetylase 2.	Interferon regulatory factor.	0.942
HDAC2	MDM2	ENSFCAP00000035237	ENSFCAP00000025067	Histone deacetylase 2.	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]	0.430
HDAC2	STAT1	ENSFCAP00000035237	ENSFCAP00000050611	Histone deacetylase 2.	Signal transducer and activator of transcription.	0.606
HDAC2	STAT2	ENSFCAP00000035237	ENSFCAP00000011155	Histone deacetylase 2.	Signal transducer and activator of transcription.	0.479
HDAC2	STAT3	ENSFCAP00000035237	ENSFCAP00000001991	Histone deacetylase 2.	Signal transducer and activator of transcription.	0.642
IRF1	CHD4	ENSFCAP00000012353	ENSFCAP00000006385	Interferon regulatory factor.	Uncharacterized protein.	0.909
IRF1	HDAC1	ENSFCAP00000012353	ENSFCAP00000033351	Interferon regulatory factor.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.942