Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
TICRRTOPBP1 interacting checkpoint and replication regulator. (1884 aa)    
Predicted Functional Partners:
TOPBP1
DNA topoisomerase II binding protein 1.
   
 
 0.987
CCNA1
Cyclin A1; Belongs to the cyclin family.
   
 0.900
CCNA2
Cyclin A2; Belongs to the cyclin family.
   
 0.889
MTBP
MDM2 binding protein.
   
 0.816
DBF4
DBF4 zinc finger.
   
  
 0.781
GINS4
DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.
   
 
 0.772
BUB1
BUB1 mitotic checkpoint serine/threonine kinase.
   
 
 0.762
CDC45
Cell division cycle 45.
   
  
 0.740
FBL
Fibrillarin.
   
 
 0.698
FANCI
FA complementation group I.
   
 
 0.694
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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