Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa)    
Predicted Functional Partners:
IRF3
Interferon regulatory factor 3.
    
 0.998
TRAF3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.997
TANK
TRAF family member associated NFKB activator.
   
 0.996
TBK1
TANK binding kinase 1.
   
 0.996
STING1
Stimulator of interferon genes.
   
 0.988
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
   
 0.987
CYLD
CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.
    
 0.985
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.973
TNF
Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]
   
 0.970
TRAF3IP2
TRAF3 interacting protein 2.
    
 0.966
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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