STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EIF4A2Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family. (407 aa)    
Predicted Functional Partners:
EIF4A1
Uncharacterized protein; Belongs to the DEAD box helicase family.
  
 
0.997
EIF4G2
Eukaryotic translation initiation factor 4 gamma 2.
   
 0.988
EIF4G3
Eukaryotic translation initiation factor 4 gamma 3.
   
 0.984
EIF4G1
Eukaryotic translation initiation factor 4 gamma 1.
   
 0.983
EIF4B
Eukaryotic translation initiation factor 4B.
   
 0.980
EIF3I
Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]
   
 
 0.900
PDCD4
Programmed cell death 4.
   
 0.898
EEF1G
Eukaryotic translation elongation factor 1 gamma.
   
 
 0.893
RPS8
40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family.
   
 0.854
EIF3B
Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family.
   
 
 0.853
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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