TMPRSS11D protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TMPRSS11D

Transmembrane protease serine; Belongs to the peptidase S1 family. (418 aa)

Predicted Functional Partners:

ENSFCAP00000036913

0.717

TMPRSS2

0.614

MET

0.557

RASSF6

0.509

ANPEP

0.459

ATP10B

0.456

AMBN

0.456

CTSV

0.448

SCARB2

0.447

FURIN

0.446

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBN	RASSF6	ENSFCAP00000008533	ENSFCAP00000012333	Ameloblastin.	Ras association domain family member 6.	0.425
AMBN	TMPRSS11D	ENSFCAP00000008533	ENSFCAP00000012906	Ameloblastin.	Transmembrane protease serine; Belongs to the peptidase S1 family.	0.456
ANPEP	CTSV	ENSFCAP00000049104	ENSFCAP00000036179	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Cathepsin V; Belongs to the peptidase C1 family.	0.445
ANPEP	ENSFCAP00000036913	ENSFCAP00000049104	ENSFCAP00000036913	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	C-type lectin domain-containing protein.	0.449
ANPEP	FURIN	ENSFCAP00000049104	ENSFCAP00000059575	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.731
ANPEP	TMPRSS11D	ENSFCAP00000049104	ENSFCAP00000012906	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Transmembrane protease serine; Belongs to the peptidase S1 family.	0.459
ANPEP	TMPRSS2	ENSFCAP00000049104	ENSFCAP00000007479	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.601
ATP10B	TMPRSS11D	ENSFCAP00000004293	ENSFCAP00000012906	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Transmembrane protease serine; Belongs to the peptidase S1 family.	0.456
CTSV	ANPEP	ENSFCAP00000036179	ENSFCAP00000049104	Cathepsin V; Belongs to the peptidase C1 family.	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	0.445
CTSV	FURIN	ENSFCAP00000036179	ENSFCAP00000059575	Cathepsin V; Belongs to the peptidase C1 family.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.750
CTSV	TMPRSS11D	ENSFCAP00000036179	ENSFCAP00000012906	Cathepsin V; Belongs to the peptidase C1 family.	Transmembrane protease serine; Belongs to the peptidase S1 family.	0.448
CTSV	TMPRSS2	ENSFCAP00000036179	ENSFCAP00000007479	Cathepsin V; Belongs to the peptidase C1 family.	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.878
ENSFCAP00000036913	ANPEP	ENSFCAP00000036913	ENSFCAP00000049104	C-type lectin domain-containing protein.	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	0.449
ENSFCAP00000036913	TMPRSS11D	ENSFCAP00000036913	ENSFCAP00000012906	C-type lectin domain-containing protein.	Transmembrane protease serine; Belongs to the peptidase S1 family.	0.717
FURIN	ANPEP	ENSFCAP00000059575	ENSFCAP00000049104	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	0.731
FURIN	CTSV	ENSFCAP00000059575	ENSFCAP00000036179	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Cathepsin V; Belongs to the peptidase C1 family.	0.750
FURIN	TMPRSS11D	ENSFCAP00000059575	ENSFCAP00000012906	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Transmembrane protease serine; Belongs to the peptidase S1 family.	0.446
FURIN	TMPRSS2	ENSFCAP00000059575	ENSFCAP00000007479	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.877
MET	TMPRSS11D	ENSFCAP00000060432	ENSFCAP00000012906	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Transmembrane protease serine; Belongs to the peptidase S1 family.	0.557
MET	TMPRSS2	ENSFCAP00000060432	ENSFCAP00000007479	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.557