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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
COX18Cytochrome c oxidase assembly factor COX18. (337 aa)    
Predicted Functional Partners:
COX2
Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]
   
 
 0.972
COX20
Cytochrome c oxidase assembly factor COX20.
      
 0.885
SEC61A2
SEC61 translocon alpha 2 subunit.
   
 0.869
SEC61A1
SEC61 translocon alpha 1 subunit.
   
 0.869
DHRS1
Dehydrogenase/reductase 1.
   
  
 0.766
MRPL45
Mitochondrial ribosomal protein L45.
   
 
 0.744
MRPL17
Mitochondrial ribosomal protein L17; Belongs to the bacterial ribosomal protein bL17 family.
   
 
 0.684
ATRNL1
Attractin like 1.
      
 0.662
MRPS9
Mitochondrial ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.
   
   0.658
MRPL58
RF_PROK_I domain-containing protein.
  
 
 0.656
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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