Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KLKlotho. (1014 aa)    
Predicted Functional Partners:
FGF23
Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.
    
 0.966
FGFR1
Fibroblast growth factor receptor.
    
 0.907
FGF19
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.874
IGF1R
Tyrosine-protein kinase receptor.
     
 0.863
FGFR4
Fibroblast growth factor receptor.
    
 0.859
GUSB
Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.
    
 0.832
RGN
Regucalcin.
  
 
 0.832
INSR
Tyrosine-protein kinase receptor.
     
 0.818
IRS4
Insulin receptor substrate 4.
    
 0.795
UGT1A
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 
 0.795
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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