Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PDLIM4PDZ and LIM domain 4. (330 aa)    
Predicted Functional Partners:
PDLIM2
PDZ and LIM domain 2.
     
 0.901
PDLIM1
PDZ and LIM domain 1.
     
  0.862
PDLIM3
PDZ and LIM domain 3.
     
  0.818
TRIP6
Thyroid hormone receptor interactor 6.
   
 
 0.798
CNN3
Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
   
 
 0.747
RSPH1
Radial spoke head component 1.
   
  
 0.699
PTPN13
Protein tyrosine phosphatase non-receptor type 13.
    
 0.690
NCKAP1
NCK associated protein 1.
   
 
 0.632
LPP
LIM domain containing preferred translocation partner in lipoma.
   
 
 0.611
GFAP
Glial fibrillary acidic protein; Belongs to the intermediate filament family.
   
 
 0.579
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.