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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MMP9Matrix metallopeptidase 9. (705 aa)    
Predicted Functional Partners:
TIMP1
TIMP metallopeptidase inhibitor 1.
   
 0.994
TIMP3
TIMP metallopeptidase inhibitor 3.
   
 0.985
THBS1
Thrombospondin 1.
   
 0.971
SRC
Tyrosine-protein kinase.
   
 0.971
CD44
CD44 molecule (Indian blood group).
   
 0.970
CDH1
Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.
    
 0.964
MMP1
Matrix metallopeptidase 1.
   
0.960
SDC1
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
    
 0.957
MMP3
Matrix metallopeptidase 3.
  
0.957
EDN1
Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.
     
 0.949
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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