STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD40CD40 molecule. (324 aa)    
Predicted Functional Partners:
CD40LG
CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]
   
 0.999
TRAF3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.986
TRAF2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.974
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.972
CD86
B-lymphocyte activation antigen B7-2 (CD86).
   
  
 0.938
CD80
B-lymphocyte activation antigen B7-1 (CD80).
   
 
 0.923
CD19
CD19 molecule.
   
  
 0.918
TRAF5
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.881
CD4
CD4 molecule.
      
 0.860
ICOS
Inducible T cell costimulator.
   
  
 0.853
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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