Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SREBF2Sterol regulatory element binding transcription factor 2. (1236 aa)    
Predicted Functional Partners:
SCAP
SREBF chaperone.
    
 0.957
KPNB1
Karyopherin subunit beta 1.
    
 0.948
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 0.871
LDLR
Low density lipoprotein receptor.
   
 
 0.865
MBTPS1
Membrane bound transcription factor peptidase, site 1.
    
 0.861
CREBBP
CREB binding protein.
    
 0.860
MBTPS2
Membrane bound transcription factor peptidase, site 2.
    
 0.838
NPC1
NPC intracellular cholesterol transporter 1.
    
 0.837
SREBF1
Sterol regulatory element binding transcription factor 1.
   
 0.831
LPIN1
Lipin 1.
    
 0.805
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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