RIPK1 protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP8	FADD	ENSFCAP00000055230	ENSFCAP00000045141	Caspase 8; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.994
CASP8	IKBKB	ENSFCAP00000055230	ENSFCAP00000044529	Caspase 8; Belongs to the peptidase C14A family.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.672
CASP8	IKBKG	ENSFCAP00000055230	ENSFCAP00000020981	Caspase 8; Belongs to the peptidase C14A family.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.737
CASP8	RIPK1	ENSFCAP00000055230	ENSFCAP00000013566	Caspase 8; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.993
CASP8	RIPK3	ENSFCAP00000055230	ENSFCAP00000005200	Caspase 8; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 3.	0.996
CASP8	TNFAIP3	ENSFCAP00000055230	ENSFCAP00000057774	Caspase 8; Belongs to the peptidase C14A family.	TNF alpha induced protein 3.	0.635
CASP8	TNFRSF1A	ENSFCAP00000055230	ENSFCAP00000006375	Caspase 8; Belongs to the peptidase C14A family.	TNF receptor superfamily member 1A.	0.769
CASP8	TRADD	ENSFCAP00000055230	ENSFCAP00000045608	Caspase 8; Belongs to the peptidase C14A family.	TNFRSF1A associated via death domain.	0.994
CASP8	TRAF6	ENSFCAP00000055230	ENSFCAP00000047805	Caspase 8; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.783
FADD	CASP8	ENSFCAP00000045141	ENSFCAP00000055230	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase 8; Belongs to the peptidase C14A family.	0.994
FADD	IKBKB	ENSFCAP00000045141	ENSFCAP00000044529	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.604
FADD	IKBKG	ENSFCAP00000045141	ENSFCAP00000020981	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.794
FADD	RIPK1	ENSFCAP00000045141	ENSFCAP00000013566	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 1.	0.998
FADD	RIPK3	ENSFCAP00000045141	ENSFCAP00000005200	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 3.	0.998
FADD	TAB2	ENSFCAP00000045141	ENSFCAP00000010485	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.539
FADD	TNFAIP3	ENSFCAP00000045141	ENSFCAP00000057774	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF alpha induced protein 3.	0.889
FADD	TNFRSF1A	ENSFCAP00000045141	ENSFCAP00000006375	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF receptor superfamily member 1A.	0.997
FADD	TRADD	ENSFCAP00000045141	ENSFCAP00000045608	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNFRSF1A associated via death domain.	0.999
FADD	TRAF6	ENSFCAP00000045141	ENSFCAP00000047805	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.957
IKBKB	CASP8	ENSFCAP00000044529	ENSFCAP00000055230	Inhibitor of nuclear factor kappa B kinase subunit beta.	Caspase 8; Belongs to the peptidase C14A family.	0.672