STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)    
Predicted Functional Partners:
NOTCH1
Notch receptor 1.
   
0.999
NOTCH3
Notch receptor 3.
    
0.992
NOTCH2
Notch receptor 2.
    
0.992
ENSFCAP00000057780
Uncharacterized protein.
   
0.980
DLL1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
  
  
0.938
DLL3
Delta like canonical Notch ligand 3.
     
0.906
EMCN
Endomucin.
   
  
 0.800
ENSFCAP00000057918
Uncharacterized protein.
   
0.794
PDGFB
Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...]
   
 0.769
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
    
 0.758
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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