Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HEPHL1Hephaestin like 1; Belongs to the multicopper oxidase family. (1157 aa)    
Predicted Functional Partners:
FXN
Frataxin.
     
 0.913
HMOX2
Heme oxygenase 2.
     
 0.904
HMOX1
Heme oxygenase 1.
     
 0.904
HEPH
Hephaestin; Belongs to the multicopper oxidase family.
     
  0.894
LOC101080399
Uncharacterized protein; Belongs to the multicopper oxidase family.
     
  0.853
CP
Ceruloplasmin; Belongs to the multicopper oxidase family.
     
  0.853
FTH1
Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
     
 0.839
SLC40A1
Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
    
 0.830
MFGE8
Milk fat globule-EGF factor 8 protein.
 
  
 0.745
TMC8
Transmembrane channel-like protein.
    
 0.684
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (20%) [HD]