Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PRPHPeripherin; Belongs to the intermediate filament family. (469 aa)    
Predicted Functional Partners:
NEFL
Neurofilament light; Belongs to the intermediate filament family.
   
  0.924
NEFM
Neurofilament medium; Belongs to the intermediate filament family.
   
  0.830
NEFH
Neurofilament heavy; Belongs to the intermediate filament family.
   
  0.830
NES
Nestin; Belongs to the intermediate filament family.
    
   0.817
INA
Internexin neuronal intermediate filament protein alpha; Belongs to the intermediate filament family.
   
  0.806
DES
Desmin; Belongs to the intermediate filament family.
   
   0.732
VIM
Vimentin; Belongs to the intermediate filament family.
   
   0.732
TRDN
Triadin.
   
  0.471
SYNC
Syncoilin, intermediate filament protein; Belongs to the intermediate filament family.
   
  0.449
PARP8
Poly [ADP-ribose] polymerase.
      
 0.446
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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