Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LRRC8ELeucine rich repeat containing 8 VRAC subunit E. (866 aa)    
Predicted Functional Partners:
LRRC8A
Leucine rich repeat containing 8 VRAC subunit A.
   
 0.980
TRIM2
Tripartite motif containing 2.
    
 0.789
LRRC8B
Pannexin_like domain-containing protein.
    
 0.755
TTYH2
Protein tweety homolog; Probable chloride channel.
      
 0.687
CORIN
Corin, serine peptidase.
   
 0.672
TRIM3
Tripartite motif containing 3.
    
 0.619
RABEPK
Rab9 effector protein with kelch motifs.
     
 0.598
TTC8
Tetratricopeptide repeat domain 8.
    
 0.597
MRC2
Mannose receptor C type 2.
    
 0.579
TTYH3
Protein tweety homolog; Probable chloride channel; Belongs to the tweety family.
      
 0.579
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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