NLRP12 protein (Felis catus) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

NLRP12

NLR family pyrin domain containing 12. (1034 aa)

Predicted Functional Partners:

PYCARD

0.954

RELA

0.915

NFKB1

0.908

CASP4

0.759

NLRC4

0.721

TAB1

0.600

HNMT

0.528

MEFV

0.523

RNASE1

0.502

CARD8

0.501

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD8	CASP4	ENSFCAP00000029752	ENSFCAP00000005500	Caspase recruitment domain family member 8.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.686
CARD8	MEFV	ENSFCAP00000029752	ENSFCAP00000033259	Caspase recruitment domain family member 8.	MEFV innate immuity regulator, pyrin.	0.602
CARD8	NLRP12	ENSFCAP00000029752	ENSFCAP00000013894	Caspase recruitment domain family member 8.	NLR family pyrin domain containing 12.	0.501
CARD8	PYCARD	ENSFCAP00000029752	ENSFCAP00000051017	Caspase recruitment domain family member 8.	PYD and CARD domain containing.	0.752
CASP4	CARD8	ENSFCAP00000005500	ENSFCAP00000029752	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Caspase recruitment domain family member 8.	0.686
CASP4	MEFV	ENSFCAP00000005500	ENSFCAP00000033259	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	MEFV innate immuity regulator, pyrin.	0.852
CASP4	NLRC4	ENSFCAP00000005500	ENSFCAP00000005570	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NLR family CARD domain containing 4.	0.941
CASP4	NLRP12	ENSFCAP00000005500	ENSFCAP00000013894	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NLR family pyrin domain containing 12.	0.759
CASP4	PYCARD	ENSFCAP00000005500	ENSFCAP00000051017	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	PYD and CARD domain containing.	0.997
HNMT	NLRP12	ENSFCAP00000030406	ENSFCAP00000013894	Histamine N-methyltransferase.	NLR family pyrin domain containing 12.	0.528
MEFV	CARD8	ENSFCAP00000033259	ENSFCAP00000029752	MEFV innate immuity regulator, pyrin.	Caspase recruitment domain family member 8.	0.602
MEFV	CASP4	ENSFCAP00000033259	ENSFCAP00000005500	MEFV innate immuity regulator, pyrin.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.852
MEFV	NLRC4	ENSFCAP00000033259	ENSFCAP00000005570	MEFV innate immuity regulator, pyrin.	NLR family CARD domain containing 4.	0.671
MEFV	NLRP12	ENSFCAP00000033259	ENSFCAP00000013894	MEFV innate immuity regulator, pyrin.	NLR family pyrin domain containing 12.	0.523
MEFV	PYCARD	ENSFCAP00000033259	ENSFCAP00000051017	MEFV innate immuity regulator, pyrin.	PYD and CARD domain containing.	0.936
NFKB1	NLRP12	ENSFCAP00000006998	ENSFCAP00000013894	Nuclear factor kappa B subunit 1.	NLR family pyrin domain containing 12.	0.908
NFKB1	RELA	ENSFCAP00000006998	ENSFCAP00000048226	Nuclear factor kappa B subunit 1.	RELA proto-oncogene, NF-kB subunit.	0.999
NLRC4	CASP4	ENSFCAP00000005570	ENSFCAP00000005500	NLR family CARD domain containing 4.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.941
NLRC4	MEFV	ENSFCAP00000005570	ENSFCAP00000033259	NLR family CARD domain containing 4.	MEFV innate immuity regulator, pyrin.	0.671
NLRC4	NLRP12	ENSFCAP00000005570	ENSFCAP00000013894	NLR family CARD domain containing 4.	NLR family pyrin domain containing 12.	0.721