STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMURF1E3 ubiquitin-protein ligase. (757 aa)    
Predicted Functional Partners:
SMAD7
Mothers against decapentaplegic homolog.
    
 0.999
SMAD6
Mothers against decapentaplegic homolog.
    
 0.993
PTCH1
Patched 1.
    
 0.983
TGFBR1
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    
 0.978
SMURF2
E3 ubiquitin-protein ligase.
  
0.975
SMAD1
Mothers against decapentaplegic homolog.
    
 0.967
PTCH2
Patched 2.
    
 0.959
SMAD3
Mothers against decapentaplegic homolog.
    
 0.851
SMAD5
Mothers against decapentaplegic homolog.
    
 0.851
SMAD4
Mothers against decapentaplegic homolog.
   
 0.842
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.