STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1137 aa)    
Predicted Functional Partners:
NOS3
Nitric oxide synthase; Produces nitric oxide (NO).
   
  
 0.936
ANGPT1
Angiopoietin 1.
   
 0.934
ANGPT2
Angiopoietin 2.
   
 0.929
LRRK1
Leucine rich repeat kinase 1.
   
 
0.803
PECAM1
Platelet and endothelial cell adhesion molecule 1.
   
 0.796
ANGPT4
Angiopoietin 4.
   
 0.784
ANGPTL7
Angiopoietin like 7.
   
 0.660
DOK2
Docking protein 2.
    
 0.651
GRB2
Growth factor receptor bound protein 2.
   
 0.645
TGFB1I1
Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.
    
 0.619
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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