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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF146Ring finger protein 146. (356 aa)    
Predicted Functional Partners:
TNKS
Poly [ADP-ribose] polymerase.
    
 0.969
TNKS2
Poly [ADP-ribose] polymerase.
    
 0.919
UBE2D1
Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.834
AXIN1
Axin 1.
    
 0.731
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
    
 
 0.730
PARP2
Poly [ADP-ribose] polymerase.
    
 
 0.728
APLF
Aprataxin and PNKP like factor.
      
 0.722
AXIN2
Axin 2.
    
 0.719
RNF167
Ring finger protein 167.
      
 0.702
SH3BP5L
SH3 binding domain protein 5 like.
    
 
 0.657
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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