Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RNF146Ring finger protein 146. (356 aa)    
Predicted Functional Partners:
TNKS
Poly [ADP-ribose] polymerase.
    
 0.983
PARP2
Poly [ADP-ribose] polymerase.
    
 
 0.948
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
    
 
 0.939
LIG3
DNA ligase.
    
 
 0.932
CHD1L
Chromodomain helicase DNA binding protein 1 like.
    
 
 0.928
TNKS2
Poly [ADP-ribose] polymerase.
    
 0.916
AXIN2
Axin 2.
    
 0.873
XRCC1
X-ray repair cross complementing 1.
    
 
 0.866
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit.
    
   0.833
XPC
XPC complex subunit, DNA damage recognition and repair factor.
    
   0.830
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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