STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SORT1Sortilin. (877 aa)    
Predicted Functional Partners:
NTS
Neurotensin.
    
 
 0.970
NGFR
Nerve growth factor receptor.
    
 0.966
APOB
Apolipoprotein B.
     
 0.935
BDNF
Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]
    
 
 0.887
NGF
Nerve growth factor; Belongs to the NGF-beta family.
    
 
 0.823
GAK
Cyclin G associated kinase.
   
 
 0.812
GRN
Granulin precursor.
    
 
 0.799
PSAP
Prosaposin.
    
 
 0.799
GGA2
Golgi associated, gamma adaptin ear containing, ARF binding protein 2.
    
 
 0.792
PSMA5
Proteasome subunit alpha type.
 
  
 
 0.783
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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