GEM protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

GEM

GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)

Predicted Functional Partners:

CACNB3

0.645

KIF9

0.626

CACNB1

0.603

HERC1

0.583

ITSN2

0.577

MDN1

0.568

NOS1AP

0.512

FRMPD2

0.500

TSC2

0.486

MTOR

0.476

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNB1	CACNB3	ENSFCAP00000027037	ENSFCAP00000040461	Calcium voltage-gated channel auxiliary subunit beta 1.	Calcium voltage-gated channel auxiliary subunit beta 3.	0.995
CACNB1	GEM	ENSFCAP00000027037	ENSFCAP00000014383	Calcium voltage-gated channel auxiliary subunit beta 1.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.603
CACNB3	CACNB1	ENSFCAP00000040461	ENSFCAP00000027037	Calcium voltage-gated channel auxiliary subunit beta 3.	Calcium voltage-gated channel auxiliary subunit beta 1.	0.995
CACNB3	GEM	ENSFCAP00000040461	ENSFCAP00000014383	Calcium voltage-gated channel auxiliary subunit beta 3.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.645
FRMPD2	GEM	ENSFCAP00000006470	ENSFCAP00000014383	FERM and PDZ domain containing 2.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.500
GEM	CACNB1	ENSFCAP00000014383	ENSFCAP00000027037	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	Calcium voltage-gated channel auxiliary subunit beta 1.	0.603
GEM	CACNB3	ENSFCAP00000014383	ENSFCAP00000040461	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	Calcium voltage-gated channel auxiliary subunit beta 3.	0.645
GEM	FRMPD2	ENSFCAP00000014383	ENSFCAP00000006470	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	FERM and PDZ domain containing 2.	0.500
GEM	HERC1	ENSFCAP00000014383	ENSFCAP00000054274	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	0.583
GEM	ITSN2	ENSFCAP00000014383	ENSFCAP00000003974	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	Intersectin 2.	0.577
GEM	KIF9	ENSFCAP00000014383	ENSFCAP00000034664	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.626
GEM	MDN1	ENSFCAP00000014383	ENSFCAP00000018747	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family.	0.568
GEM	MTOR	ENSFCAP00000014383	ENSFCAP00000000048	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.476
GEM	NOS1AP	ENSFCAP00000014383	ENSFCAP00000052885	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	PID domain-containing protein.	0.512
GEM	TSC2	ENSFCAP00000014383	ENSFCAP00000033801	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	TSC complex subunit 2.	0.486
HERC1	GEM	ENSFCAP00000054274	ENSFCAP00000014383	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.583
HERC1	MDN1	ENSFCAP00000054274	ENSFCAP00000018747	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family.	0.592
ITSN2	GEM	ENSFCAP00000003974	ENSFCAP00000014383	Intersectin 2.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.577
ITSN2	NOS1AP	ENSFCAP00000003974	ENSFCAP00000052885	Intersectin 2.	PID domain-containing protein.	0.697
KIF9	GEM	ENSFCAP00000034664	ENSFCAP00000014383	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family.	0.626