ERLIN2 protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ERLIN2

ER lipid raft associated 2. (337 aa)

Predicted Functional Partners:

RNF185

0.876

THAP1

0.817

RNF5

0.805

SEL1L

0.785

PHB2

0.783

ZNF703

0.753

OS9

0.724

CB2H6orf120

0.718

DERL1

0.713

PLPBP

0.711

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CB2H6orf120	ERLIN2	ENSFCAP00000024636	ENSFCAP00000014406	Chromosome B2 C6orf120 homolog.	ER lipid raft associated 2.	0.718
CB2H6orf120	RNF185	ENSFCAP00000024636	ENSFCAP00000044613	Chromosome B2 C6orf120 homolog.	Ring finger protein 185.	0.765
CB2H6orf120	RNF5	ENSFCAP00000024636	ENSFCAP00000004182	Chromosome B2 C6orf120 homolog.	Ring finger protein 5.	0.651
CB2H6orf120	THAP1	ENSFCAP00000024636	ENSFCAP00000030668	Chromosome B2 C6orf120 homolog.	Ring finger protein 170.	0.757
DERL1	ERLIN2	ENSFCAP00000023495	ENSFCAP00000014406	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	ER lipid raft associated 2.	0.713
DERL1	OS9	ENSFCAP00000023495	ENSFCAP00000013629	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	OS9 endoplasmic reticulum lectin.	0.968
DERL1	RNF185	ENSFCAP00000023495	ENSFCAP00000044613	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ring finger protein 185.	0.703
DERL1	RNF5	ENSFCAP00000023495	ENSFCAP00000004182	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ring finger protein 5.	0.781
DERL1	SEL1L	ENSFCAP00000023495	ENSFCAP00000008368	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.970
ERLIN2	CB2H6orf120	ENSFCAP00000014406	ENSFCAP00000024636	ER lipid raft associated 2.	Chromosome B2 C6orf120 homolog.	0.718
ERLIN2	DERL1	ENSFCAP00000014406	ENSFCAP00000023495	ER lipid raft associated 2.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.713
ERLIN2	OS9	ENSFCAP00000014406	ENSFCAP00000013629	ER lipid raft associated 2.	OS9 endoplasmic reticulum lectin.	0.724
ERLIN2	PHB2	ENSFCAP00000014406	ENSFCAP00000021501	ER lipid raft associated 2.	Prohibitin.	0.783
ERLIN2	PLPBP	ENSFCAP00000014406	ENSFCAP00000055999	ER lipid raft associated 2.	Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6.	0.711
ERLIN2	RNF185	ENSFCAP00000014406	ENSFCAP00000044613	ER lipid raft associated 2.	Ring finger protein 185.	0.876
ERLIN2	RNF5	ENSFCAP00000014406	ENSFCAP00000004182	ER lipid raft associated 2.	Ring finger protein 5.	0.805
ERLIN2	SEL1L	ENSFCAP00000014406	ENSFCAP00000008368	ER lipid raft associated 2.	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.	0.785
ERLIN2	THAP1	ENSFCAP00000014406	ENSFCAP00000030668	ER lipid raft associated 2.	Ring finger protein 170.	0.817
ERLIN2	ZNF703	ENSFCAP00000014406	ENSFCAP00000039981	ER lipid raft associated 2.	Zinc finger protein 703.	0.753
OS9	DERL1	ENSFCAP00000013629	ENSFCAP00000023495	OS9 endoplasmic reticulum lectin.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.968