STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated killer cells, and stimulate the production of IFN-gamma by resting PBMC; Belongs to the type I cytokine receptor family. Type 3 subfamily (329 aa)    
Predicted Functional Partners:
IL12A
Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC
    
 0.983
IL23R
Interleukin 23 receptor
    
 0.925
IL12RB2
Interleukin 12 receptor, beta 2
    
 0.923
IL12RB1
Interleukin 12 receptor, beta 1
    
 0.923
IL23A
Interleukin 23, alpha subunit p19
    
 
 0.918
IFNGR2
Interferon gamma receptor 2 (interferon gamma transducer 1)
     
 0.719
IL10
Interleukin-10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells
   
  
 0.712
IFNGR1
Interferon gamma receptor 1
     
 0.663
FN1
Fibronectin 1
    
   0.662
IL2RG
Interleukin 2 receptor, gamma
   
 
 0.642
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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