STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (409 aa)    
Predicted Functional Partners:
BABAM2
BRISC and BRCA1 A complex member 2.
    
 0.999
BRCC3
BRCA1/BRCA2-containing complex subunit 3.
    
 0.999
BABAM1
Uncharacterized protein.
    
 0.999
BRCA1
Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]
    
 0.998
UIMC1
Ubiquitin interaction motif containing 1.
    
 0.998
BARD1
BRCA1 associated RING domain 1.
    
 0.993
ANKRD12
Ankyrin repeat domain 12.
    
 0.822
MYSM1
Myb like, SWIRM and MPN domains 1.
    
 0.793
MPND
MPN domain containing.
    
 0.793
PSMD14
Proteasome 26S subunit, non-ATPase 14.
    
 0.793
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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