| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOB | APP | ENSFCAP00000023369 | ENSFCAP00000001445 | Apolipoprotein B. | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | 0.677 |
| APOB | BCHE | ENSFCAP00000023369 | ENSFCAP00000026088 | Apolipoprotein B. | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity); Belongs to the type-B carboxylesterase/lipase family. | 0.721 |
| APOB | BRCA2 | ENSFCAP00000023369 | ENSFCAP00000019777 | Apolipoprotein B. | Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] | 0.536 |
| APOB | PON1 | ENSFCAP00000023369 | ENSFCAP00000035990 | Apolipoprotein B. | Paraoxonase 1. | 0.544 |
| APOB | RAG2 | ENSFCAP00000023369 | ENSFCAP00000039073 | Apolipoprotein B. | Recombination activating 2. | 0.712 |
| APP | APOB | ENSFCAP00000001445 | ENSFCAP00000023369 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Apolipoprotein B. | 0.677 |
| APP | BACE1 | ENSFCAP00000001445 | ENSFCAP00000000163 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.995 |
| APP | BCHE | ENSFCAP00000001445 | ENSFCAP00000026088 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity); Belongs to the type-B carboxylesterase/lipase family. | 0.836 |
| APP | CHAT | ENSFCAP00000001445 | ENSFCAP00000027471 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. | 0.402 |
| APP | RAG2 | ENSFCAP00000001445 | ENSFCAP00000039073 | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | Recombination activating 2. | 0.590 |
| BACE1 | APP | ENSFCAP00000000163 | ENSFCAP00000001445 | Beta-secretase 1; Belongs to the peptidase A1 family. | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | 0.995 |
| BACE1 | BCHE | ENSFCAP00000000163 | ENSFCAP00000026088 | Beta-secretase 1; Belongs to the peptidase A1 family. | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity); Belongs to the type-B carboxylesterase/lipase family. | 0.646 |
| BCHE | APOB | ENSFCAP00000026088 | ENSFCAP00000023369 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity); Belongs to the type-B carboxylesterase/lipase family. | Apolipoprotein B. | 0.721 |
| BCHE | APP | ENSFCAP00000026088 | ENSFCAP00000001445 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity); Belongs to the type-B carboxylesterase/lipase family. | Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...] | 0.836 |
| BCHE | BACE1 | ENSFCAP00000026088 | ENSFCAP00000000163 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity); Belongs to the type-B carboxylesterase/lipase family. | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.646 |
| BCHE | BRCA2 | ENSFCAP00000026088 | ENSFCAP00000019777 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity); Belongs to the type-B carboxylesterase/lipase family. | Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] | 0.669 |
| BCHE | CHAT | ENSFCAP00000026088 | ENSFCAP00000027471 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity); Belongs to the type-B carboxylesterase/lipase family. | Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. | 0.872 |
| BCHE | COLQ | ENSFCAP00000026088 | ENSFCAP00000029111 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity); Belongs to the type-B carboxylesterase/lipase family. | Collagen like tail subunit of asymmetric acetylcholinesterase. | 0.805 |
| BCHE | GHRL | ENSFCAP00000026088 | ENSFCAP00000010442 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity); Belongs to the type-B carboxylesterase/lipase family. | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | 0.771 |
| BCHE | GPCPD1 | ENSFCAP00000026088 | ENSFCAP00000015585 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity); Belongs to the type-B carboxylesterase/lipase family. | Glycerophosphocholine phosphodiesterase 1. | 0.744 |
