node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F13B | F2 | ENSFCAP00000004646 | ENSFCAP00000017324 | Coagulation factor XIII B chain. | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | 0.991 |
F13B | F5 | ENSFCAP00000004646 | ENSFCAP00000007547 | Coagulation factor XIII B chain. | Coagulation factor V; Belongs to the multicopper oxidase family. | 0.671 |
F13B | FGA | ENSFCAP00000004646 | ENSFCAP00000003022 | Coagulation factor XIII B chain. | Fibrinogen alpha chain. | 0.920 |
F13B | FGB | ENSFCAP00000004646 | ENSFCAP00000012290 | Coagulation factor XIII B chain. | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] | 0.743 |
F13B | FGG | ENSFCAP00000004646 | ENSFCAP00000055064 | Coagulation factor XIII B chain. | Fibrinogen gamma chain. | 0.776 |
F13B | SERPINC1 | ENSFCAP00000004646 | ENSFCAP00000013843 | Coagulation factor XIII B chain. | Serpin family C member 1; Belongs to the serpin family. | 0.801 |
F13B | SERPIND1 | ENSFCAP00000004646 | ENSFCAP00000005577 | Coagulation factor XIII B chain. | Serpin family D member 1; Belongs to the serpin family. | 0.867 |
F2 | F13B | ENSFCAP00000017324 | ENSFCAP00000004646 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Coagulation factor XIII B chain. | 0.991 |
F2 | F2R | ENSFCAP00000017324 | ENSFCAP00000003064 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | 0.997 |
F2 | F2RL3 | ENSFCAP00000017324 | ENSFCAP00000054408 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.996 |
F2 | F5 | ENSFCAP00000017324 | ENSFCAP00000007547 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Coagulation factor V; Belongs to the multicopper oxidase family. | 0.998 |
F2 | FGA | ENSFCAP00000017324 | ENSFCAP00000003022 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Fibrinogen alpha chain. | 0.998 |
F2 | FGB | ENSFCAP00000017324 | ENSFCAP00000012290 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] | 0.997 |
F2 | FGG | ENSFCAP00000017324 | ENSFCAP00000055064 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Fibrinogen gamma chain. | 0.996 |
F2 | SERPINC1 | ENSFCAP00000017324 | ENSFCAP00000013843 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Serpin family C member 1; Belongs to the serpin family. | 0.999 |
F2 | SERPIND1 | ENSFCAP00000017324 | ENSFCAP00000005577 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Serpin family D member 1; Belongs to the serpin family. | 0.999 |
F2 | THBD | ENSFCAP00000017324 | ENSFCAP00000010694 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Thrombomodulin. | 0.997 |
F2R | F2 | ENSFCAP00000003064 | ENSFCAP00000017324 | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | 0.997 |
F2R | F2RL3 | ENSFCAP00000003064 | ENSFCAP00000054408 | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.930 |
F2R | FGG | ENSFCAP00000003064 | ENSFCAP00000055064 | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | Fibrinogen gamma chain. | 0.487 |