STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)    
Predicted Functional Partners:
PIM1
Serine/threonine-protein kinase pim-1; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly th [...]
  
  
 
0.902
CRNKL1
Crooked neck pre-mRNA splicing factor 1.
      
 0.590
KANSL2
KAT8 regulatory NSL complex subunit 2.
      
 0.555
PRKAB1
Protein kinase AMP-activated non-catalytic subunit beta 1.
    
 0.537
PRKAB2
Protein kinase AMP-activated non-catalytic subunit beta 2.
    
 0.537
PRCC
Proline rich mitotic checkpoint control factor.
    
 
 0.527
HAUS7
HAUS augmin like complex subunit 7.
      
 0.525
PRKAG3
Protein kinase AMP-activated non-catalytic subunit gamma 3.
   
 0.514
PRKAG2
Protein kinase AMP-activated non-catalytic subunit gamma 2.
   
 0.514
PRKAG1
Protein kinase AMP-activated non-catalytic subunit gamma 1.
   
 0.514
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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