| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EP300 | ESR1 | ENSFCAP00000004636 | ENSFCAP00000020448 | E1A binding protein p300. | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.984 |
| EP300 | ESR2 | ENSFCAP00000004636 | ENSFCAP00000042538 | E1A binding protein p300. | Estrogen receptor 2. | 0.857 |
| EP300 | JUN | ENSFCAP00000004636 | ENSFCAP00000021043 | E1A binding protein p300. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.961 |
| EP300 | MED1 | ENSFCAP00000004636 | ENSFCAP00000044432 | E1A binding protein p300. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.916 |
| EP300 | NCOA1 | ENSFCAP00000004636 | ENSFCAP00000042028 | E1A binding protein p300. | Nuclear receptor coactivator. | 0.995 |
| EP300 | NCOA2 | ENSFCAP00000004636 | ENSFCAP00000018792 | E1A binding protein p300. | Nuclear receptor coactivator. | 0.982 |
| EP300 | NCOA3 | ENSFCAP00000004636 | ENSFCAP00000013944 | E1A binding protein p300. | Nuclear receptor coactivator. | 0.995 |
| EP300 | NCOR1 | ENSFCAP00000004636 | ENSFCAP00000033436 | E1A binding protein p300. | Nuclear receptor corepressor 1. | 0.854 |
| EP300 | PGR | ENSFCAP00000004636 | ENSFCAP00000049487 | E1A binding protein p300. | Progesterone receptor. | 0.705 |
| EP300 | SP1 | ENSFCAP00000004636 | ENSFCAP00000016457 | E1A binding protein p300. | Sp1 transcription factor. | 0.991 |
| ESR1 | EP300 | ENSFCAP00000020448 | ENSFCAP00000004636 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | E1A binding protein p300. | 0.984 |
| ESR1 | ESR2 | ENSFCAP00000020448 | ENSFCAP00000042538 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Estrogen receptor 2. | 0.996 |
| ESR1 | JUN | ENSFCAP00000020448 | ENSFCAP00000021043 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.989 |
| ESR1 | MED1 | ENSFCAP00000020448 | ENSFCAP00000044432 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.992 |
| ESR1 | NCOA1 | ENSFCAP00000020448 | ENSFCAP00000042028 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor coactivator. | 0.996 |
| ESR1 | NCOA2 | ENSFCAP00000020448 | ENSFCAP00000018792 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor coactivator. | 0.994 |
| ESR1 | NCOA3 | ENSFCAP00000020448 | ENSFCAP00000013944 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor coactivator. | 0.996 |
| ESR1 | NCOR1 | ENSFCAP00000020448 | ENSFCAP00000033436 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor corepressor 1. | 0.994 |
| ESR1 | PGR | ENSFCAP00000020448 | ENSFCAP00000049487 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Progesterone receptor. | 0.988 |
| ESR1 | SP1 | ENSFCAP00000020448 | ENSFCAP00000016457 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Sp1 transcription factor. | 0.991 |
