NLRP3 protein (Felis catus) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

NLRP3

NLR family pyrin domain containing 3. (1038 aa)

Predicted Functional Partners:

PYCARD

0.998

TXNIP

0.984

IL1B

0.969

NEK7

0.966

CARD8

0.960

BRCC3

0.952

CTSB

0.937

NFKB1

0.934

SLC29A1

0.926

HSP90AA1

0.926

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCC3	NLRP3	ENSFCAP00000040001	ENSFCAP00000020543	BRCA1/BRCA2-containing complex subunit 3.	NLR family pyrin domain containing 3.	0.952
CARD8	IL1B	ENSFCAP00000029752	ENSFCAP00000005482	Caspase recruitment domain family member 8.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.414
CARD8	NLRP3	ENSFCAP00000029752	ENSFCAP00000020543	Caspase recruitment domain family member 8.	NLR family pyrin domain containing 3.	0.960
CARD8	PYCARD	ENSFCAP00000029752	ENSFCAP00000051017	Caspase recruitment domain family member 8.	PYD and CARD domain containing.	0.752
CTSB	IL1B	ENSFCAP00000051086	ENSFCAP00000005482	Cathepsin B; Belongs to the peptidase C1 family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.574
CTSB	NLRP3	ENSFCAP00000051086	ENSFCAP00000020543	Cathepsin B; Belongs to the peptidase C1 family.	NLR family pyrin domain containing 3.	0.937
HSP90AA1	NLRP3	ENSFCAP00000041549	ENSFCAP00000020543	Heat shock protein 90 alpha family class A member 1.	NLR family pyrin domain containing 3.	0.926
HSP90AA1	SLC29A1	ENSFCAP00000041549	ENSFCAP00000009056	Heat shock protein 90 alpha family class A member 1.	Heat shock protein 90 alpha family class B member 1.	0.902
IL1B	CARD8	ENSFCAP00000005482	ENSFCAP00000029752	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Caspase recruitment domain family member 8.	0.414
IL1B	CTSB	ENSFCAP00000005482	ENSFCAP00000051086	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Cathepsin B; Belongs to the peptidase C1 family.	0.574
IL1B	NEK7	ENSFCAP00000005482	ENSFCAP00000040569	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	NIMA related kinase 7; Belongs to the protein kinase superfamily.	0.417
IL1B	NFKB1	ENSFCAP00000005482	ENSFCAP00000006998	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Nuclear factor kappa B subunit 1.	0.956
IL1B	NLRP3	ENSFCAP00000005482	ENSFCAP00000020543	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	NLR family pyrin domain containing 3.	0.969
IL1B	PYCARD	ENSFCAP00000005482	ENSFCAP00000051017	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	PYD and CARD domain containing.	0.983
IL1B	TXNIP	ENSFCAP00000005482	ENSFCAP00000023477	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Thioredoxin interacting protein.	0.581
NEK7	IL1B	ENSFCAP00000040569	ENSFCAP00000005482	NIMA related kinase 7; Belongs to the protein kinase superfamily.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.417
NEK7	NLRP3	ENSFCAP00000040569	ENSFCAP00000020543	NIMA related kinase 7; Belongs to the protein kinase superfamily.	NLR family pyrin domain containing 3.	0.966
NEK7	PYCARD	ENSFCAP00000040569	ENSFCAP00000051017	NIMA related kinase 7; Belongs to the protein kinase superfamily.	PYD and CARD domain containing.	0.710
NFKB1	IL1B	ENSFCAP00000006998	ENSFCAP00000005482	Nuclear factor kappa B subunit 1.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.956
NFKB1	NLRP3	ENSFCAP00000006998	ENSFCAP00000020543	Nuclear factor kappa B subunit 1.	NLR family pyrin domain containing 3.	0.934