node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | BIRC3 | ENSFCAP00000047198 | ENSFCAP00000013003 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 3. | 0.705 |
APAF1 | CASP10 | ENSFCAP00000047198 | ENSFCAP00000004373 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 10; Belongs to the peptidase C14A family. | 0.841 |
APAF1 | CASP3 | ENSFCAP00000047198 | ENSFCAP00000031946 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | 0.995 |
APAF1 | CASP8 | ENSFCAP00000047198 | ENSFCAP00000055230 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 8; Belongs to the peptidase C14A family. | 0.942 |
APAF1 | CASP9 | ENSFCAP00000047198 | ENSFCAP00000018153 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 9; Belongs to the peptidase C14A family. | 0.999 |
APAF1 | LOC101100947 | ENSFCAP00000047198 | ENSFCAP00000022576 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.998 |
APAF1 | XIAP | ENSFCAP00000047198 | ENSFCAP00000011167 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | X-linked inhibitor of apoptosis. | 0.872 |
BIRC3 | APAF1 | ENSFCAP00000013003 | ENSFCAP00000047198 | Baculoviral IAP repeat containing 3. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.705 |
BIRC3 | CASP10 | ENSFCAP00000013003 | ENSFCAP00000004373 | Baculoviral IAP repeat containing 3. | Caspase 10; Belongs to the peptidase C14A family. | 0.509 |
BIRC3 | CASP3 | ENSFCAP00000013003 | ENSFCAP00000031946 | Baculoviral IAP repeat containing 3. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | 0.990 |
BIRC3 | CASP8 | ENSFCAP00000013003 | ENSFCAP00000055230 | Baculoviral IAP repeat containing 3. | Caspase 8; Belongs to the peptidase C14A family. | 0.521 |
BIRC3 | CASP9 | ENSFCAP00000013003 | ENSFCAP00000018153 | Baculoviral IAP repeat containing 3. | Caspase 9; Belongs to the peptidase C14A family. | 0.979 |
BIRC3 | XIAP | ENSFCAP00000013003 | ENSFCAP00000011167 | Baculoviral IAP repeat containing 3. | X-linked inhibitor of apoptosis. | 0.991 |
CASP10 | APAF1 | ENSFCAP00000004373 | ENSFCAP00000047198 | Caspase 10; Belongs to the peptidase C14A family. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.841 |
CASP10 | BIRC3 | ENSFCAP00000004373 | ENSFCAP00000013003 | Caspase 10; Belongs to the peptidase C14A family. | Baculoviral IAP repeat containing 3. | 0.509 |
CASP10 | CASP3 | ENSFCAP00000004373 | ENSFCAP00000031946 | Caspase 10; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | 0.978 |
CASP10 | CASP8 | ENSFCAP00000004373 | ENSFCAP00000055230 | Caspase 10; Belongs to the peptidase C14A family. | Caspase 8; Belongs to the peptidase C14A family. | 0.978 |
CASP10 | CASP9 | ENSFCAP00000004373 | ENSFCAP00000018153 | Caspase 10; Belongs to the peptidase C14A family. | Caspase 9; Belongs to the peptidase C14A family. | 0.733 |
CASP10 | LOC101100947 | ENSFCAP00000004373 | ENSFCAP00000022576 | Caspase 10; Belongs to the peptidase C14A family. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.605 |
CASP10 | XIAP | ENSFCAP00000004373 | ENSFCAP00000011167 | Caspase 10; Belongs to the peptidase C14A family. | X-linked inhibitor of apoptosis. | 0.579 |