node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | FGA | ENSFCAP00000028536 | ENSFCAP00000003022 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Fibrinogen alpha chain. | 0.689 |
ALB | FGB | ENSFCAP00000028536 | ENSFCAP00000012290 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] | 0.677 |
ALB | PLAT | ENSFCAP00000028536 | ENSFCAP00000034342 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Plasminogen activator; Belongs to the peptidase S1 family. | 0.652 |
ALB | PLAU | ENSFCAP00000028536 | ENSFCAP00000045022 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Plasminogen activator, urokinase. | 0.506 |
ALB | PLG | ENSFCAP00000028536 | ENSFCAP00000021289 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.979 |
ALB | SERPINC1 | ENSFCAP00000028536 | ENSFCAP00000013843 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Serpin family C member 1; Belongs to the serpin family. | 0.554 |
F12 | FGA | ENSFCAP00000058307 | ENSFCAP00000003022 | Coagulation factor XII. | Fibrinogen alpha chain. | 0.403 |
F12 | FGB | ENSFCAP00000058307 | ENSFCAP00000012290 | Coagulation factor XII. | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] | 0.453 |
F12 | HRG | ENSFCAP00000058307 | ENSFCAP00000012868 | Coagulation factor XII. | Histidine rich glycoprotein. | 0.592 |
F12 | PLAUR | ENSFCAP00000058307 | ENSFCAP00000004849 | Coagulation factor XII. | Plasminogen activator, urokinase receptor. | 0.419 |
F12 | PLG | ENSFCAP00000058307 | ENSFCAP00000021289 | Coagulation factor XII. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.961 |
F12 | SERPINC1 | ENSFCAP00000058307 | ENSFCAP00000013843 | Coagulation factor XII. | Serpin family C member 1; Belongs to the serpin family. | 0.954 |
F12 | SERPINF2 | ENSFCAP00000058307 | ENSFCAP00000005854 | Coagulation factor XII. | Serpin family F member 2; Belongs to the serpin family. | 0.483 |
FGA | ALB | ENSFCAP00000003022 | ENSFCAP00000028536 | Fibrinogen alpha chain. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | 0.689 |
FGA | F12 | ENSFCAP00000003022 | ENSFCAP00000058307 | Fibrinogen alpha chain. | Coagulation factor XII. | 0.403 |
FGA | FGB | ENSFCAP00000003022 | ENSFCAP00000012290 | Fibrinogen alpha chain. | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] | 0.999 |
FGA | HRG | ENSFCAP00000003022 | ENSFCAP00000012868 | Fibrinogen alpha chain. | Histidine rich glycoprotein. | 0.688 |
FGA | PLAT | ENSFCAP00000003022 | ENSFCAP00000034342 | Fibrinogen alpha chain. | Plasminogen activator; Belongs to the peptidase S1 family. | 0.444 |
FGA | PLG | ENSFCAP00000003022 | ENSFCAP00000021289 | Fibrinogen alpha chain. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.953 |
FGA | SERPINC1 | ENSFCAP00000003022 | ENSFCAP00000013843 | Fibrinogen alpha chain. | Serpin family C member 1; Belongs to the serpin family. | 0.948 |