node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACE2 | AGT | ENSFCAP00000052000 | ENSFCAP00000022349 | Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...] | Angiotensinogen; Belongs to the serpin family. | 0.943 |
ACE2 | DPP4 | ENSFCAP00000052000 | ENSFCAP00000037887 | Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...] | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | 0.993 |
ACE2 | NPEPPS | ENSFCAP00000052000 | ENSFCAP00000022045 | Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...] | Aminopeptidase. | 0.554 |
ACE2 | XPNPEP2 | ENSFCAP00000052000 | ENSFCAP00000007478 | Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...] | X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family. | 0.911 |
AGT | ACE2 | ENSFCAP00000022349 | ENSFCAP00000052000 | Angiotensinogen; Belongs to the serpin family. | Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...] | 0.943 |
AGT | LOC101083124 | ENSFCAP00000022349 | ENSFCAP00000055535 | Angiotensinogen; Belongs to the serpin family. | Angiotensin-converting enzyme. | 0.948 |
AGT | NPEPPS | ENSFCAP00000022349 | ENSFCAP00000022045 | Angiotensinogen; Belongs to the serpin family. | Aminopeptidase. | 0.719 |
BLMH | NPEPPS | ENSFCAP00000003738 | ENSFCAP00000022045 | Bleomycin hydrolase; Belongs to the peptidase C1 family. | Aminopeptidase. | 0.738 |
DNPEP | LAP3 | ENSFCAP00000044614 | ENSFCAP00000057261 | Aspartyl aminopeptidase; Belongs to the peptidase M18 family. | Leucine aminopeptidase 3. | 0.526 |
DNPEP | NPEPPS | ENSFCAP00000044614 | ENSFCAP00000022045 | Aspartyl aminopeptidase; Belongs to the peptidase M18 family. | Aminopeptidase. | 0.544 |
DNPEP | XPNPEP1 | ENSFCAP00000044614 | ENSFCAP00000003247 | Aspartyl aminopeptidase; Belongs to the peptidase M18 family. | X-prolyl aminopeptidase 1; Belongs to the peptidase M24B family. | 0.403 |
DNPEP | XPNPEP2 | ENSFCAP00000044614 | ENSFCAP00000007478 | Aspartyl aminopeptidase; Belongs to the peptidase M18 family. | X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family. | 0.403 |
DNPEP | XPNPEP3 | ENSFCAP00000044614 | ENSFCAP00000052507 | Aspartyl aminopeptidase; Belongs to the peptidase M18 family. | X-prolyl aminopeptidase 3. | 0.445 |
DPP4 | ACE2 | ENSFCAP00000037887 | ENSFCAP00000052000 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...] | 0.993 |
DPP4 | LOC101083124 | ENSFCAP00000037887 | ENSFCAP00000055535 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | Angiotensin-converting enzyme. | 0.483 |
DPP4 | NPEPPS | ENSFCAP00000037887 | ENSFCAP00000022045 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | Aminopeptidase. | 0.588 |
DPP4 | XPNPEP2 | ENSFCAP00000037887 | ENSFCAP00000007478 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family. | 0.919 |
LAP3 | DNPEP | ENSFCAP00000057261 | ENSFCAP00000044614 | Leucine aminopeptidase 3. | Aspartyl aminopeptidase; Belongs to the peptidase M18 family. | 0.526 |
LAP3 | NPEPPS | ENSFCAP00000057261 | ENSFCAP00000022045 | Leucine aminopeptidase 3. | Aminopeptidase. | 0.597 |
LAP3 | XPNPEP1 | ENSFCAP00000057261 | ENSFCAP00000003247 | Leucine aminopeptidase 3. | X-prolyl aminopeptidase 1; Belongs to the peptidase M24B family. | 0.606 |