STRINGSTRING
IL6 protein (Felis catus) - STRING interaction network
"IL6" - Interleukin-6 precursor in Felis catus
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL6Interleukin-6 precursor ; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myelo [...] (208 aa)    
Predicted Functional Partners:
IL6R
Interleukin 6 receptor (440 aa)
       
  0.991
IL6ST
Interleukin 6 signal transducer (gp130, oncostatin M receptor) (918 aa)
       
  0.987
NFKB1
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (966 aa)
     
  0.976
FOS
Proto-oncogene c-Fos ; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 a [...] (381 aa)
     
 
  0.952
JAK2
Janus kinase 2 (1133 aa)
     
 
  0.942
LEPR
Leptin receptor (1166 aa)
         
  0.933
JAK1
Janus kinase 1 (1155 aa)
     
 
  0.932
JAK3
Janus kinase 3 (1138 aa)
     
 
  0.932
IL2RA
Interleukin-2 receptor subunit alpha ; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells (268 aa)
         
  0.929
JUN
Jun proto-oncogene (317 aa)
     
 
  0.927
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felidae, Feliformia, Felinae, Felis, Felis catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cat family, cats, domestic cat
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