node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | HGF | ENSFCAP00000041464 | ENSFCAP00000033735 | Receptor protein-tyrosine kinase. | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). | 0.883 |
EGFR | IGF1 | ENSFCAP00000041464 | ENSFCAP00000042016 | Receptor protein-tyrosine kinase. | Insulin like growth factor 1. | 0.952 |
EGFR | PDGFA | ENSFCAP00000041464 | ENSFCAP00000023057 | Receptor protein-tyrosine kinase. | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | 0.926 |
EGFR | PDGFB | ENSFCAP00000041464 | ENSFCAP00000014447 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] | 0.930 |
EGFR | PDGFC | ENSFCAP00000041464 | ENSFCAP00000056969 | Receptor protein-tyrosine kinase. | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.937 |
EGFR | PDGFD | ENSFCAP00000041464 | ENSFCAP00000052577 | Receptor protein-tyrosine kinase. | Platelet derived growth factor D. | 0.920 |
EGFR | PDGFRA | ENSFCAP00000041464 | ENSFCAP00000008478 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.957 |
EGFR | PDGFRB | ENSFCAP00000041464 | ENSFCAP00000003349 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.959 |
EGFR | TGFA | ENSFCAP00000041464 | ENSFCAP00000040793 | Receptor protein-tyrosine kinase. | Transforming growth factor alpha. | 0.998 |
EGFR | VEGFC | ENSFCAP00000041464 | ENSFCAP00000007408 | Receptor protein-tyrosine kinase. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.743 |
HGF | EGFR | ENSFCAP00000033735 | ENSFCAP00000041464 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). | Receptor protein-tyrosine kinase. | 0.883 |
HGF | IGF1 | ENSFCAP00000033735 | ENSFCAP00000042016 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). | Insulin like growth factor 1. | 0.971 |
HGF | PDGFA | ENSFCAP00000033735 | ENSFCAP00000023057 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | 0.920 |
HGF | PDGFB | ENSFCAP00000033735 | ENSFCAP00000014447 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] | 0.923 |
HGF | PDGFC | ENSFCAP00000033735 | ENSFCAP00000056969 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.928 |
HGF | PDGFD | ENSFCAP00000033735 | ENSFCAP00000052577 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). | Platelet derived growth factor D. | 0.921 |
HGF | PDGFRA | ENSFCAP00000033735 | ENSFCAP00000008478 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.735 |
HGF | PDGFRB | ENSFCAP00000033735 | ENSFCAP00000003349 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.762 |
HGF | TGFA | ENSFCAP00000033735 | ENSFCAP00000040793 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). | Transforming growth factor alpha. | 0.415 |
HGF | VEGFC | ENSFCAP00000033735 | ENSFCAP00000007408 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.943 |