STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SYCP3Synaptonemal complex protein 3. (236 aa)    
Predicted Functional Partners:
BRCA2
Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...]
    
 0.910
LOC111558739
Cor1 domain-containing protein.
  
  
 
0.902
LOC105260238
Cor1 domain-containing protein.
  
  
 
0.902
SYCE3
Synaptonemal complex central element protein 3.
     
 0.853
SYCP1
Synaptonemal complex protein 1.
    
 0.839
REC8
REC8 meiotic recombination protein.
    
 0.811
SPO11
SPO11 initiator of meiotic double stranded breaks.
      
 0.775
DAZL
Deleted in azoospermia like.
    
 
 0.759
MLH1
MutL homolog 1.
      
 0.722
STRA8
Stimulated by retinoic acid 8.
      
 0.715
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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