node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | CPT1A | ENSFCAP00000001979 | ENSFCAP00000053728 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. | 0.606 |
ACLY | ELOVL6 | ENSFCAP00000001979 | ENSFCAP00000036736 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] | 0.659 |
ACLY | FASN | ENSFCAP00000001979 | ENSFCAP00000010847 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Fatty acid synthase. | 0.993 |
ACLY | HMGCS1 | ENSFCAP00000001979 | ENSFCAP00000011120 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.895 |
ACLY | PPARG | ENSFCAP00000001979 | ENSFCAP00000050722 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.460 |
ACLY | SCD | ENSFCAP00000001979 | ENSFCAP00000025038 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. | 0.664 |
ACLY | SREBF1 | ENSFCAP00000001979 | ENSFCAP00000001834 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Sterol regulatory element binding transcription factor 1. | 0.673 |
CPT1A | ACLY | ENSFCAP00000053728 | ENSFCAP00000001979 | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.606 |
CPT1A | DGAT1 | ENSFCAP00000053728 | ENSFCAP00000007153 | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. | O-acyltransferase. | 0.537 |
CPT1A | ELOVL6 | ENSFCAP00000053728 | ENSFCAP00000036736 | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] | 0.418 |
CPT1A | FASN | ENSFCAP00000053728 | ENSFCAP00000010847 | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. | Fatty acid synthase. | 0.714 |
CPT1A | PPARG | ENSFCAP00000053728 | ENSFCAP00000050722 | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.721 |
CPT1A | SCD | ENSFCAP00000053728 | ENSFCAP00000025038 | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. | Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. | 0.662 |
CPT1A | SREBF1 | ENSFCAP00000053728 | ENSFCAP00000001834 | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. | Sterol regulatory element binding transcription factor 1. | 0.560 |
DGAT1 | CPT1A | ENSFCAP00000007153 | ENSFCAP00000053728 | O-acyltransferase. | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. | 0.537 |
DGAT1 | FASN | ENSFCAP00000007153 | ENSFCAP00000010847 | O-acyltransferase. | Fatty acid synthase. | 0.701 |
DGAT1 | PPARG | ENSFCAP00000007153 | ENSFCAP00000050722 | O-acyltransferase. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.580 |
DGAT1 | SCD | ENSFCAP00000007153 | ENSFCAP00000025038 | O-acyltransferase. | Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. | 0.671 |
DGAT1 | SREBF1 | ENSFCAP00000007153 | ENSFCAP00000001834 | O-acyltransferase. | Sterol regulatory element binding transcription factor 1. | 0.638 |
ELOVL6 | ACLY | ENSFCAP00000036736 | ENSFCAP00000001979 | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.659 |