STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAV1Caveolin-1; Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G- protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wn [...] (178 aa)    
Predicted Functional Partners:
CAV2
Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...]
   
0.962
NOS3
Nitric oxide synthase; Produces nitric oxide (NO)
   
 0.956
EGFR
Receptor protein-tyrosine kinase
   
 0.952
FLOT2
Flotillin 2
   
 
 0.948
FLOT1
Flotillin 1
   
 
 0.936
SRC
Tyrosine-protein kinase; SRC proto-oncogene, non-receptor tyrosine kinase
    
 0.929
FYN
FYN proto-oncogene, Src family tyrosine kinase
    
 0.919
PTRF
Caveolae associated protein 1; Polymerase I and transcript release factor
   
 
 0.897
HSP90AA1
Heat shock protein 90kDa alpha (cytosolic), class A member 1
    
 0.862
CALM2
Calmodulin 2 (phosphorylase kinase, delta)
    
 0.853
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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