ENSFCAP00000026171 protein (Felis catus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

ENSFCAP00000026171

Uncharacterized protein. (110 aa)

Predicted Functional Partners:

RPL23

0.998

RPL8

0.998

RPL19

0.998

RPL7A

0.998

RPL6

0.997

RPL4

0.997

RPL13

0.997

RPL3

0.996

RPL13A

0.996

RPS16

0.996

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFCAP00000026171	RPL13	ENSFCAP00000026171	ENSFCAP00000062065	Uncharacterized protein.	Uncharacterized protein.	0.997
ENSFCAP00000026171	RPL13A	ENSFCAP00000026171	ENSFCAP00000008520	Uncharacterized protein.	Ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family.	0.996
ENSFCAP00000026171	RPL19	ENSFCAP00000026171	ENSFCAP00000028930	Uncharacterized protein.	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	0.998
ENSFCAP00000026171	RPL23	ENSFCAP00000026171	ENSFCAP00000013451	Uncharacterized protein.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.998
ENSFCAP00000026171	RPL3	ENSFCAP00000026171	ENSFCAP00000005405	Uncharacterized protein.	Ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	0.996
ENSFCAP00000026171	RPL4	ENSFCAP00000026171	ENSFCAP00000011405	Uncharacterized protein.	Ribosomal protein L4.	0.997
ENSFCAP00000026171	RPL6	ENSFCAP00000026171	ENSFCAP00000006368	Uncharacterized protein.	60S ribosomal protein L6; Belongs to the eukaryotic ribosomal protein eL6 family.	0.997
ENSFCAP00000026171	RPL7A	ENSFCAP00000026171	ENSFCAP00000044690	Uncharacterized protein.	Ribosomal protein L7a.	0.998
ENSFCAP00000026171	RPL8	ENSFCAP00000026171	ENSFCAP00000017067	Uncharacterized protein.	Ribosomal protein L8.	0.998
ENSFCAP00000026171	RPS16	ENSFCAP00000026171	ENSFCAP00000009979	Uncharacterized protein.	Ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family.	0.996
RPL13	ENSFCAP00000026171	ENSFCAP00000062065	ENSFCAP00000026171	Uncharacterized protein.	Uncharacterized protein.	0.997
RPL13	RPL13A	ENSFCAP00000062065	ENSFCAP00000008520	Uncharacterized protein.	Ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family.	0.999
RPL13	RPL19	ENSFCAP00000062065	ENSFCAP00000028930	Uncharacterized protein.	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	0.999
RPL13	RPL23	ENSFCAP00000062065	ENSFCAP00000013451	Uncharacterized protein.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.999
RPL13	RPL3	ENSFCAP00000062065	ENSFCAP00000005405	Uncharacterized protein.	Ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	0.999
RPL13	RPL4	ENSFCAP00000062065	ENSFCAP00000011405	Uncharacterized protein.	Ribosomal protein L4.	0.999
RPL13	RPL6	ENSFCAP00000062065	ENSFCAP00000006368	Uncharacterized protein.	60S ribosomal protein L6; Belongs to the eukaryotic ribosomal protein eL6 family.	0.999
RPL13	RPL7A	ENSFCAP00000062065	ENSFCAP00000044690	Uncharacterized protein.	Ribosomal protein L7a.	0.999
RPL13	RPL8	ENSFCAP00000062065	ENSFCAP00000017067	Uncharacterized protein.	Ribosomal protein L8.	0.999
RPL13	RPS16	ENSFCAP00000062065	ENSFCAP00000009979	Uncharacterized protein.	Ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family.	0.998

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.915

expected number of edges:

13

PPI enrichment p-value:

0.00139

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030198

Extracellular matrix organization

3 of 3

2.58

1.93

0.00027

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008658

Penicillin binding

6 of 22

2.02

3.53

1.27e-08

GO:0005201

Extracellular matrix structural constituent

3 of 3

2.58

2.5

2.21e-05

GO:0008955

Peptidoglycan glycosyltransferase activity

2 of 5

2.19

1.08

0.0095

GO:0009002

Serine-type D-Ala-D-Ala carboxypeptidase activity

2 of 9

1.93

0.87

0.0220

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031012

Extracellular matrix

3 of 3

2.58

2.43

2.96e-05

GO:0005615

Extracellular space

3 of 3

2.58

2.43

2.96e-05

GO:0005887

Integral component of plasma membrane

4 of 78

1.29

1.11

0.0011

GO:0071944

Cell periphery

7 of 655

0.61

0.44

0.0067

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2028

Mixed, incl. Penicillin-binding protein, transpeptidase, and Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal

6 of 12

2.28

4.57

3.03e-10

CL:1996

Peptidoglycan biosynthesis, and Alanine racemase

7 of 29

1.97

4.01

2.39e-10

CL:2030

Penicillin-binding protein, transpeptidase, and Cell cycle, FtsW / RodA / SpoVE, conserved site

4 of 6

2.41

3.28

4.40e-07

CL:1986

Mixed, incl. Peptidoglycan biosynthesis, and Extracellular region

10 of 140

1.44

2.62

2.11e-11

CL:2169

Mixed, incl. Extracellular space, and Xylanase activity

3 of 20

1.76

1.34

0.0017

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

6 of 42

1.74

2.79

7.49e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005576

Extracellular region

4 of 98

1.2

0.69

0.0221

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00905

Penicillin binding protein transpeptidase domain

4 of 7

2.34

2.78

4.06e-06

PF03717

Penicillin-binding Protein dimerisation domain

3 of 3

2.58

2.25

6.54e-05

PF01391

Collagen triple helix repeat (20 copies)

2 of 3

2.41

1.08

0.0102

PF00912

Transglycosylase

2 of 4

2.28

1.05

0.0115

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001460

Penicillin-binding protein, transpeptidase

4 of 7

2.34

2.59

1.01e-05

IPR036138

Penicillin-binding protein, dimerisation domain superfamily

3 of 3

2.58

2.14

0.00011

IPR005311

Penicillin-binding protein, dimerisation domain

3 of 3

2.58

2.14

0.00011

IPR012338

Beta-lactamase/transpeptidase-like

4 of 17

1.96

1.97

9.00e-05

IPR008160

Collagen triple helix repeat

2 of 2

2.58

1.12

0.0092

(more ...)

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