STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMYD1SET and MYND domain containing 1. (490 aa)    
Predicted Functional Partners:
SMYD5
SMYD family member 5.
      
 0.786
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
   
 0.773
ASH2L
ASH2 like, histone lysine methyltransferase complex subunit.
    
 0.748
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
    
 0.723
PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1.
   
 0.677
PLOD3
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3.
   
 0.677
CAMKMT
Calmodulin-lysine N-methyltransferase.
     
 0.677
PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2.
   
 0.677
TEX37
Testis expressed 37.
      
 0.636
UNC45B
Unc-45 myosin chaperone B.
   
  
 0.611
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.