node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCL2 | CASP10 | ENSFCAP00000062072 | ENSFCAP00000004373 | BCL2 apoptosis regulator. | Caspase 10; Belongs to the peptidase C14A family. | 0.582 |
BCL2 | CASP3 | ENSFCAP00000062072 | ENSFCAP00000031946 | BCL2 apoptosis regulator. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | 0.936 |
BCL2 | CASP8 | ENSFCAP00000062072 | ENSFCAP00000055230 | BCL2 apoptosis regulator. | Caspase 8; Belongs to the peptidase C14A family. | 0.894 |
BCL2 | CASP9 | ENSFCAP00000062072 | ENSFCAP00000018153 | BCL2 apoptosis regulator. | Caspase 9; Belongs to the peptidase C14A family. | 0.920 |
BCL2 | FADD | ENSFCAP00000062072 | ENSFCAP00000045141 | BCL2 apoptosis regulator. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.640 |
BCL2 | FAS | ENSFCAP00000062072 | ENSFCAP00000026574 | BCL2 apoptosis regulator. | Uncharacterized protein. | 0.545 |
BCL2 | FASLG | ENSFCAP00000062072 | ENSFCAP00000033003 | BCL2 apoptosis regulator. | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] | 0.731 |
BCL2 | IFNG | ENSFCAP00000062072 | ENSFCAP00000008355 | BCL2 apoptosis regulator. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.611 |
BCL2 | TRADD | ENSFCAP00000062072 | ENSFCAP00000045608 | BCL2 apoptosis regulator. | TNFRSF1A associated via death domain. | 0.508 |
CASP10 | BCL2 | ENSFCAP00000004373 | ENSFCAP00000062072 | Caspase 10; Belongs to the peptidase C14A family. | BCL2 apoptosis regulator. | 0.582 |
CASP10 | CASP3 | ENSFCAP00000004373 | ENSFCAP00000031946 | Caspase 10; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | 0.978 |
CASP10 | CASP8 | ENSFCAP00000004373 | ENSFCAP00000055230 | Caspase 10; Belongs to the peptidase C14A family. | Caspase 8; Belongs to the peptidase C14A family. | 0.978 |
CASP10 | CASP9 | ENSFCAP00000004373 | ENSFCAP00000018153 | Caspase 10; Belongs to the peptidase C14A family. | Caspase 9; Belongs to the peptidase C14A family. | 0.733 |
CASP10 | FADD | ENSFCAP00000004373 | ENSFCAP00000045141 | Caspase 10; Belongs to the peptidase C14A family. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.996 |
CASP10 | FAS | ENSFCAP00000004373 | ENSFCAP00000026574 | Caspase 10; Belongs to the peptidase C14A family. | Uncharacterized protein. | 0.920 |
CASP10 | FASLG | ENSFCAP00000004373 | ENSFCAP00000033003 | Caspase 10; Belongs to the peptidase C14A family. | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] | 0.815 |
CASP10 | TRADD | ENSFCAP00000004373 | ENSFCAP00000045608 | Caspase 10; Belongs to the peptidase C14A family. | TNFRSF1A associated via death domain. | 0.981 |
CASP3 | BCL2 | ENSFCAP00000031946 | ENSFCAP00000062072 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | BCL2 apoptosis regulator. | 0.936 |
CASP3 | CASP10 | ENSFCAP00000031946 | ENSFCAP00000004373 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | Caspase 10; Belongs to the peptidase C14A family. | 0.978 |
CASP3 | CASP8 | ENSFCAP00000031946 | ENSFCAP00000055230 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | Caspase 8; Belongs to the peptidase C14A family. | 0.997 |