USP7 protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

USP7

Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1107 aa)

Predicted Functional Partners:

RPS27A

0.991

LOC109502223

0.991

MDM2

0.989

ENSFCAP00000026617

0.989

UVSSA

0.973

FOXO4

0.973

FOXO1

0.959

FOXO3

0.958

FOXO6

0.958

DNMT1

0.952

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNMT1	ENSFCAP00000026617	ENSFCAP00000044002	ENSFCAP00000026617	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Ubiquitin-like domain-containing protein.	0.973
DNMT1	LOC109502223	ENSFCAP00000044002	ENSFCAP00000032729	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Ubiquitin-like domain-containing protein.	0.651
DNMT1	MDM2	ENSFCAP00000044002	ENSFCAP00000025067	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]	0.455
DNMT1	RPS27A	ENSFCAP00000044002	ENSFCAP00000018695	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Ribosomal protein S27a.	0.651
DNMT1	USP7	ENSFCAP00000044002	ENSFCAP00000034512	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.952
ENSFCAP00000026617	DNMT1	ENSFCAP00000026617	ENSFCAP00000044002	Ubiquitin-like domain-containing protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.973
ENSFCAP00000026617	LOC109502223	ENSFCAP00000026617	ENSFCAP00000032729	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.996
ENSFCAP00000026617	MDM2	ENSFCAP00000026617	ENSFCAP00000025067	Ubiquitin-like domain-containing protein.	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]	0.919
ENSFCAP00000026617	RPS27A	ENSFCAP00000026617	ENSFCAP00000018695	Ubiquitin-like domain-containing protein.	Ribosomal protein S27a.	0.996
ENSFCAP00000026617	USP7	ENSFCAP00000026617	ENSFCAP00000034512	Ubiquitin-like domain-containing protein.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.989
FOXO1	FOXO3	ENSFCAP00000039549	ENSFCAP00000022859	Forkhead box O1.	Forkhead box O3.	0.953
FOXO1	FOXO4	ENSFCAP00000039549	ENSFCAP00000031271	Forkhead box O1.	Forkhead box O4.	0.562
FOXO1	FOXO6	ENSFCAP00000039549	ENSFCAP00000049848	Forkhead box O1.	Forkhead box O6.	0.456
FOXO1	MDM2	ENSFCAP00000039549	ENSFCAP00000025067	Forkhead box O1.	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]	0.667
FOXO1	USP7	ENSFCAP00000039549	ENSFCAP00000034512	Forkhead box O1.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.959
FOXO3	FOXO1	ENSFCAP00000022859	ENSFCAP00000039549	Forkhead box O3.	Forkhead box O1.	0.953
FOXO3	FOXO4	ENSFCAP00000022859	ENSFCAP00000031271	Forkhead box O3.	Forkhead box O4.	0.595
FOXO3	MDM2	ENSFCAP00000022859	ENSFCAP00000025067	Forkhead box O3.	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]	0.758
FOXO3	USP7	ENSFCAP00000022859	ENSFCAP00000034512	Forkhead box O3.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.958
FOXO4	FOXO1	ENSFCAP00000031271	ENSFCAP00000039549	Forkhead box O4.	Forkhead box O1.	0.562