HDAC4 protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HDAC4

Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)

Predicted Functional Partners:

CAMK4

0.910

RUNX2

0.843

ARID4B

0.821

ARID4A

0.821

NCOR2

0.812

LOC101087401

0.784

RANBP2

0.778

MACROH2A1

0.764

MACROH2A2

0.764

H2BC18

0.752

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	ARID4B	ENSFCAP00000044525	ENSFCAP00000040021	AT-rich interaction domain 4A.	AT-rich interaction domain 4B.	0.867
ARID4A	HDAC4	ENSFCAP00000044525	ENSFCAP00000036456	AT-rich interaction domain 4A.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.821
ARID4A	LOC101087401	ENSFCAP00000044525	ENSFCAP00000026602	AT-rich interaction domain 4A.	Histone H2A; Belongs to the histone H2A family.	0.751
ARID4B	ARID4A	ENSFCAP00000040021	ENSFCAP00000044525	AT-rich interaction domain 4B.	AT-rich interaction domain 4A.	0.867
ARID4B	HDAC4	ENSFCAP00000040021	ENSFCAP00000036456	AT-rich interaction domain 4B.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.821
ARID4B	LOC101087401	ENSFCAP00000040021	ENSFCAP00000026602	AT-rich interaction domain 4B.	Histone H2A; Belongs to the histone H2A family.	0.751
ARID4B	MACROH2A1	ENSFCAP00000040021	ENSFCAP00000012912	AT-rich interaction domain 4B.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.420
CAMK4	HDAC4	ENSFCAP00000001440	ENSFCAP00000036456	Calcium/calmodulin dependent protein kinase IV.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.910
H2BC18	HDAC4	ENSFCAP00000009538	ENSFCAP00000036456	Histone H2B; Belongs to the histone H2B family.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.752
H2BC18	LOC101087401	ENSFCAP00000009538	ENSFCAP00000026602	Histone H2B; Belongs to the histone H2B family.	Histone H2A; Belongs to the histone H2A family.	0.647
H2BC18	MACROH2A1	ENSFCAP00000009538	ENSFCAP00000012912	Histone H2B; Belongs to the histone H2B family.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.550
H2BC18	MACROH2A2	ENSFCAP00000009538	ENSFCAP00000043583	Histone H2B; Belongs to the histone H2B family.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.550
HDAC4	ARID4A	ENSFCAP00000036456	ENSFCAP00000044525	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	AT-rich interaction domain 4A.	0.821
HDAC4	ARID4B	ENSFCAP00000036456	ENSFCAP00000040021	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	AT-rich interaction domain 4B.	0.821
HDAC4	CAMK4	ENSFCAP00000036456	ENSFCAP00000001440	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Calcium/calmodulin dependent protein kinase IV.	0.910
HDAC4	H2BC18	ENSFCAP00000036456	ENSFCAP00000009538	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone H2B; Belongs to the histone H2B family.	0.752
HDAC4	LOC101087401	ENSFCAP00000036456	ENSFCAP00000026602	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone H2A; Belongs to the histone H2A family.	0.784
HDAC4	MACROH2A1	ENSFCAP00000036456	ENSFCAP00000012912	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.764
HDAC4	MACROH2A2	ENSFCAP00000036456	ENSFCAP00000043583	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.764
HDAC4	NCOR2	ENSFCAP00000036456	ENSFCAP00000024270	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Nuclear receptor corepressor 2.	0.812

page 1 of 2

Server load: low (26%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2023

Credits

Access

Info

About