STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAPK8Mitogen-activated protein kinase. (427 aa)    
Predicted Functional Partners:
MAP2K4
Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.
  
0.993
JUN
Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.
    
 0.993
MAPK9
Mitogen-activated protein kinase.
  
 
0.990
MAP2K7
Mitogen-activated protein kinase kinase 7.
   
0.981
JUND
JunD proto-oncogene, AP-1 transcription factor subunit.
    
 0.973
FOS
Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...]
    
 0.972
MAPK8IP1
Mitogen-activated protein kinase 8 interacting protein 1.
   
 0.967
NFATC3
Nuclear factor of activated T cells 3.
    
 0.966
BAD
BCL2 associated agonist of cell death.
    
 0.962
MAP3K1
Mitogen-activated protein kinase kinase kinase 1.
    
0.961
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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