node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF3 | BTG2 | ENSFCAP00000025287 | ENSFCAP00000040032 | Activating transcription factor 3. | BTG anti-proliferation factor 2. | 0.538 |
ATF3 | CDKN1A | ENSFCAP00000025287 | ENSFCAP00000020450 | Activating transcription factor 3. | Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] | 0.468 |
ATF3 | GADD45A | ENSFCAP00000025287 | ENSFCAP00000040077 | Activating transcription factor 3. | Growth arrest and DNA damage-inducible protein GADD45 alpha; Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). | 0.658 |
ATF3 | TP53 | ENSFCAP00000025287 | ENSFCAP00000045749 | Activating transcription factor 3. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.789 |
AURKA | AURKB | ENSFCAP00000018157 | ENSFCAP00000052302 | Aurora kinase A; Belongs to the protein kinase superfamily. | Aurora kinase B; Belongs to the protein kinase superfamily. | 0.837 |
AURKA | CDK1 | ENSFCAP00000018157 | ENSFCAP00000013888 | Aurora kinase A; Belongs to the protein kinase superfamily. | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. | 0.856 |
AURKA | ENSFCAP00000060774 | ENSFCAP00000018157 | ENSFCAP00000060774 | Aurora kinase A; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein. | 0.841 |
AURKA | GADD45A | ENSFCAP00000018157 | ENSFCAP00000040077 | Aurora kinase A; Belongs to the protein kinase superfamily. | Growth arrest and DNA damage-inducible protein GADD45 alpha; Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). | 0.942 |
AURKA | TP53 | ENSFCAP00000018157 | ENSFCAP00000045749 | Aurora kinase A; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.963 |
AURKB | AURKA | ENSFCAP00000052302 | ENSFCAP00000018157 | Aurora kinase B; Belongs to the protein kinase superfamily. | Aurora kinase A; Belongs to the protein kinase superfamily. | 0.837 |
AURKB | CDK1 | ENSFCAP00000052302 | ENSFCAP00000013888 | Aurora kinase B; Belongs to the protein kinase superfamily. | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. | 0.970 |
AURKB | ENSFCAP00000060774 | ENSFCAP00000052302 | ENSFCAP00000060774 | Aurora kinase B; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein. | 0.967 |
AURKB | GADD45A | ENSFCAP00000052302 | ENSFCAP00000040077 | Aurora kinase B; Belongs to the protein kinase superfamily. | Growth arrest and DNA damage-inducible protein GADD45 alpha; Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). | 0.580 |
AURKB | TP53 | ENSFCAP00000052302 | ENSFCAP00000045749 | Aurora kinase B; Belongs to the protein kinase superfamily. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.760 |
BTG2 | ATF3 | ENSFCAP00000040032 | ENSFCAP00000025287 | BTG anti-proliferation factor 2. | Activating transcription factor 3. | 0.538 |
BTG2 | CDKN1A | ENSFCAP00000040032 | ENSFCAP00000020450 | BTG anti-proliferation factor 2. | Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] | 0.549 |
BTG2 | GADD45A | ENSFCAP00000040032 | ENSFCAP00000040077 | BTG anti-proliferation factor 2. | Growth arrest and DNA damage-inducible protein GADD45 alpha; Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). | 0.571 |
BTG2 | TP53 | ENSFCAP00000040032 | ENSFCAP00000045749 | BTG anti-proliferation factor 2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.487 |
CDK1 | AURKA | ENSFCAP00000013888 | ENSFCAP00000018157 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. | Aurora kinase A; Belongs to the protein kinase superfamily. | 0.856 |
CDK1 | AURKB | ENSFCAP00000013888 | ENSFCAP00000052302 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. | Aurora kinase B; Belongs to the protein kinase superfamily. | 0.970 |