node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABRAXAS1 | ANKRD12 | ENSFCAP00000016018 | ENSFCAP00000044082 | Abraxas 1, BRCA1 A complex subunit. | Ankyrin repeat domain 12. | 0.822 |
ABRAXAS1 | BRCA1 | ENSFCAP00000016018 | ENSFCAP00000012193 | Abraxas 1, BRCA1 A complex subunit. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.998 |
ABRAXAS1 | MRE11 | ENSFCAP00000016018 | ENSFCAP00000022057 | Abraxas 1, BRCA1 A complex subunit. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.711 |
ABRAXAS1 | NBN | ENSFCAP00000016018 | ENSFCAP00000051686 | Abraxas 1, BRCA1 A complex subunit. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.691 |
ABRAXAS1 | RBBP8 | ENSFCAP00000016018 | ENSFCAP00000016856 | Abraxas 1, BRCA1 A complex subunit. | RB binding protein 8, endonuclease. | 0.615 |
ANKRD12 | ABRAXAS1 | ENSFCAP00000044082 | ENSFCAP00000016018 | Ankyrin repeat domain 12. | Abraxas 1, BRCA1 A complex subunit. | 0.822 |
ANKRD12 | BRCA1 | ENSFCAP00000044082 | ENSFCAP00000012193 | Ankyrin repeat domain 12. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.909 |
ANKRD12 | BRIP1 | ENSFCAP00000044082 | ENSFCAP00000015577 | Ankyrin repeat domain 12. | BRCA1 interacting protein C-terminal helicase 1. | 0.679 |
ANKRD12 | MRE11 | ENSFCAP00000044082 | ENSFCAP00000022057 | Ankyrin repeat domain 12. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.808 |
ANKRD12 | NBN | ENSFCAP00000044082 | ENSFCAP00000051686 | Ankyrin repeat domain 12. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.791 |
ANKRD12 | RAD50 | ENSFCAP00000044082 | ENSFCAP00000016131 | Ankyrin repeat domain 12. | Zinc-hook domain-containing protein. | 0.710 |
ANKRD12 | RAD51 | ENSFCAP00000044082 | ENSFCAP00000058685 | Ankyrin repeat domain 12. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.686 |
ANKRD12 | RBBP8 | ENSFCAP00000044082 | ENSFCAP00000016856 | Ankyrin repeat domain 12. | RB binding protein 8, endonuclease. | 0.868 |
ANKRD12 | TOPBP1 | ENSFCAP00000044082 | ENSFCAP00000061271 | Ankyrin repeat domain 12. | DNA topoisomerase II binding protein 1. | 0.803 |
ANKRD12 | UBA52 | ENSFCAP00000044082 | ENSFCAP00000009037 | Ankyrin repeat domain 12. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] | 0.682 |
BRCA1 | ABRAXAS1 | ENSFCAP00000012193 | ENSFCAP00000016018 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Abraxas 1, BRCA1 A complex subunit. | 0.998 |
BRCA1 | ANKRD12 | ENSFCAP00000012193 | ENSFCAP00000044082 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Ankyrin repeat domain 12. | 0.909 |
BRCA1 | BRIP1 | ENSFCAP00000012193 | ENSFCAP00000015577 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | BRCA1 interacting protein C-terminal helicase 1. | 0.987 |
BRCA1 | MRE11 | ENSFCAP00000012193 | ENSFCAP00000022057 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.991 |
BRCA1 | NBN | ENSFCAP00000012193 | ENSFCAP00000051686 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.928 |