STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSFCAP00000044608Uncharacterized protein. (516 aa)    
Predicted Functional Partners:
LOC101086271
Uncharacterized protein.
  
0.769
TGFB1
Transforming growth factor beta; Belongs to the TGF-beta family.
   
 0.726
TMPRSS6
Transmembrane serine protease 6.
    
 0.642
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
 0.591
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
   
 0.589
TMPRSS3
Transmembrane serine protease 3; Belongs to the peptidase S1 family.
    
 0.582
DPP4
Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...]
    
 
 0.555
SDC1
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
    
 0.552
REL
REL proto-oncogene, NF-kB subunit.
   
 0.551
RELB
RELB proto-oncogene, NF-kB subunit.
   
 0.551
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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