STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARHGEF18Uncharacterized protein. (1357 aa)    
Predicted Functional Partners:
RHOA
Ras homolog family member A.
   
 0.995
CGN
Cingulin.
     
 0.982
PATJ
PATJ crumbs cell polarity complex component.
   
 0.918
EPB41L4B
Erythrocyte membrane protein band 4.1 like 4B.
     
 0.912
STK11
Serine/threonine kinase 11; Belongs to the protein kinase superfamily.
     
 0.908
F11R
Junctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) In case of orthoreovirus infection, serves as rec [...]
     
 0.731
RND1
Rho family GTPase 1.
   
 0.629
RND3
Rho family GTPase 3.
   
 0.629
RHOF
Ras homolog family member F, filopodia associated.
   
 0.589
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor 6.
    
 0.573
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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