STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa)    
Predicted Functional Partners:
MAPK8IP1
Mitogen-activated protein kinase 8 interacting protein 1.
     
 0.930
MAP3K11
Mitogen-activated protein kinase kinase kinase.
   
0.916
MAPK8IP2
Mitogen-activated protein kinase 8 interacting protein 2.
     
 0.901
GRAP2
GRB2 related adaptor protein 2.
   
 
 0.868
GRB2
Growth factor receptor bound protein 2.
   
 
 0.654
CRK
CRK proto-oncogene, adaptor protein.
    
 
 0.577
LCP2
Lymphocyte cytosolic protein 2.
   
 
 0.562
RASGRP4
RAS guanyl releasing protein 4.
   
 
 0.521
NCK1
Cytoplasmic protein.
    
 
 0.520
PDIA6
Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family.
    
 
 0.512
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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