DROSHA protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	DDX5	ENSFCAP00000002557	ENSFCAP00000003241	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.420
AGO2	DGCR8	ENSFCAP00000002557	ENSFCAP00000027619	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DGCR8 microprocessor complex subunit.	0.746
AGO2	DROSHA	ENSFCAP00000002557	ENSFCAP00000050725	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Drosha ribonuclease III.	0.870
AGO2	XPO5	ENSFCAP00000002557	ENSFCAP00000031162	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Exportin 5.	0.830
DDX17	DDX5	ENSFCAP00000027708	ENSFCAP00000003241	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.996
DDX17	DGCR8	ENSFCAP00000027708	ENSFCAP00000027619	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DGCR8 microprocessor complex subunit.	0.759
DDX17	DROSHA	ENSFCAP00000027708	ENSFCAP00000050725	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Drosha ribonuclease III.	0.970
DDX17	LOC101084379	ENSFCAP00000027708	ENSFCAP00000018204	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Homeobox domain-containing protein.	0.467
DDX17	NANOG	ENSFCAP00000027708	ENSFCAP00000001505	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Nanog homeobox.	0.467
DDX21	DDX50	ENSFCAP00000038652	ENSFCAP00000023971	DExD-box helicase 21.	DExD-box helicase 50.	0.955
DDX21	DROSHA	ENSFCAP00000038652	ENSFCAP00000050725	DExD-box helicase 21.	Drosha ribonuclease III.	0.797
DDX21	SETX	ENSFCAP00000038652	ENSFCAP00000031771	DExD-box helicase 21.	Senataxin.	0.439
DDX5	AGO2	ENSFCAP00000003241	ENSFCAP00000002557	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.420
DDX5	DDX17	ENSFCAP00000003241	ENSFCAP00000027708	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.996
DDX5	DGCR8	ENSFCAP00000003241	ENSFCAP00000027619	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DGCR8 microprocessor complex subunit.	0.748
DDX5	DROSHA	ENSFCAP00000003241	ENSFCAP00000050725	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Drosha ribonuclease III.	0.993
DDX5	LOC101084379	ENSFCAP00000003241	ENSFCAP00000018204	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Homeobox domain-containing protein.	0.787
DDX5	NANOG	ENSFCAP00000003241	ENSFCAP00000001505	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Nanog homeobox.	0.787
DDX5	SETX	ENSFCAP00000003241	ENSFCAP00000031771	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Senataxin.	0.447
DDX50	DDX21	ENSFCAP00000023971	ENSFCAP00000038652	DExD-box helicase 50.	DExD-box helicase 21.	0.955